Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-
CMK
CAS: 821794-90-5
Molecular Formula: C18H19ClN4O2
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro- - Names and Identifiers
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro- - Physico-chemical Properties
| Molecular Formula | C18H19ClN4O2 |
| Molar Mass | 358.82 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 170-172°C |
| Boling Point | 647.5±55.0 °C(Predicted) |
| Solubility | Chloroform, methanol |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| pKa | 14.43±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | CMK inhibits the growth of Cdc5 (L158G) with IC 50 of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC 50 of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration. |
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.787 ml | 13.934 ml | 27.868 ml |
| 5 mM | 0.557 ml | 2.787 ml | 5.574 ml |
| 10 mM | 0.279 ml | 1.393 ml | 2.787 ml |
| 5 mM | 0.056 ml | 0.279 ml | 0.557 ml |
Last Update：2024-01-02 23:10:35
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro- - Reference Information
| biological activity | cmks are RSK2 kinase inhibitors with similar potency but lower chemical stability than fmks. |
Last Update：2024-04-09 21:04:16
![Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-](http://res.chembk.com/assets/str/2d/8/82/821794-90-5.png)
Supplier List
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: CMK Visit Supplier Webpage Request for quotation
CAS: 821794-90-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 821794-90-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: CMK Visit Supplier Webpage Request for quotationCAS: 821794-90-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: CMK Visit Supplier Webpage Request for quotation
CAS: 821794-90-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 821794-90-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-
UNII-388VZ25DUR
Phenol, 2,3,5,6-tetrafluoro-4-iodo-
Benzenamine, 4-chloro-N-[1-(methylthio)-2-nitroethenyl]-
1H-Furo[3,2-c]pyrazole-3,5-diamine, 1-hydroxy-N,N-dimethyl-, 2-oxide (9CI)
6-(1,1-Dimethylethyl)-thieno[2,3-d]pyrimidin-4(1H)-one
236-243-6
N-[4-(aminosulfonyl)phenyl]-3-ethoxybenzamide
351417-43-1
N6-(cis-4-Hydroxy-3-methylbut-2-enylamino)-9-beta-D-ribofuranosylpurine
UNII-388VZ25DUR
Phenol, 2,3,5,6-tetrafluoro-4-iodo-
Benzenamine, 4-chloro-N-[1-(methylthio)-2-nitroethenyl]-
1H-Furo[3,2-c]pyrazole-3,5-diamine, 1-hydroxy-N,N-dimethyl-, 2-oxide (9CI)
6-(1,1-Dimethylethyl)-thieno[2,3-d]pyrimidin-4(1H)-one
236-243-6
N-[4-(aminosulfonyl)phenyl]-3-ethoxybenzamide
351417-43-1
N6-(cis-4-Hydroxy-3-methylbut-2-enylamino)-9-beta-D-ribofuranosylpurine